High-Density Lipoprotein (HDL) Phospholipid Content and Cholesterol Efflux Capacity Are Reduced in Patients With Very High HDL Cholesterol and Coronary Disease | Zendy

Anandita Agarwala | Zendy; Amrith Rodrigues | Zendy; Marjorie Risman | Zendy; Mary McCoy | Zendy; Kevin Trindade | Zendy; Liming Qu | Zendy; Marina Cuchel | Zendy; Jeffrey T. Billheimer | Zendy; Daniel J. Rader | Zendy

Open Access

High-Density Lipoprotein (HDL) Phospholipid Content and Cholesterol Efflux Capacity Are Reduced in Patients With Very High HDL Cholesterol and Coronary Disease

Author(s) -

Anandita Agarwala,

Amrith Rodrigues,

Marjorie Risman,

Mary McCoy,

Kevin Trindade,

Liming Qu,

Marina Cuchel,

Jeffrey T. Billheimer,

Daniel J. Rader

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305504

Subject(s) - cholesterol , medicine , coronary artery disease , endocrinology , high density lipoprotein , phospholipid , efflux , reverse cholesterol transport , lipoprotein , biology , biochemistry , membrane

Plasma levels of high-density lipoprotein cholesterol (HDL-C) are strongly inversely associated with coronary artery disease (CAD), and high HDL-C is generally associated with reduced risk of CAD. Extremely high HDL-C with CAD is an unusual phenotype, and we hypothesized that the HDL in such individuals may have an altered composition and reduced function when compared with controls with similarly high HDL-C and no CAD.

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