Lean and Obese Coronary Perivascular Adipose Tissue Impairs Vasodilation via Differential Inhibition of Vascular Smooth Muscle K + Channels | Zendy

Jillian N. Noblet | Zendy; Meredith K. Owen | Zendy; Adam G. Goodwill | Zendy; Daniel Sassoon | Zendy; Johnathan D. Tune | Zendy

Open Access

Lean and Obese Coronary Perivascular Adipose Tissue Impairs Vasodilation via Differential Inhibition of Vascular Smooth Muscle K ⁺ Channels

Author(s) -

Jillian N. Noblet,

Meredith K. Owen,

Adam G. Goodwill,

Daniel Sassoon,

Johnathan D. Tune

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305500

Subject(s) - vasodilation , medicine , coronary arteries , endocrinology , adipose tissue , vascular smooth muscle , cardiology , adipocyte , artery , smooth muscle

The effects of coronary perivascular adipose tissue (PVAT) on vasomotor tone are influenced by an obese phenotype and are distinct from other adipose tissue depots. The purpose of this investigation was to examine the effects of lean and obese coronary PVAT on end-effector mechanisms of coronary vasodilation and to identify potential factors involved.

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