Loss of Interleukin-21 Receptor Activation in Hypoxic Endothelial Cells Impairs Perfusion Recovery After Hindlimb Ischemia | Zendy

Tao Wang | Zendy; Alexis Cunningham | Zendy; Ayotunde O. Dokun | Zendy; Surovi Hazarika | Zendy; Kevin Houston | Zendy; Lingdan Chen | Zendy; R. John Lye | Zendy; Rosanne Spolski | Zendy; Warren J. Leonard | Zendy; Brian H. Annex | Zendy

Open Access

Loss of Interleukin-21 Receptor Activation in Hypoxic Endothelial Cells Impairs Perfusion Recovery After Hindlimb Ischemia

Author(s) -

Tao Wang,

Alexis Cunningham,

Ayotunde O. Dokun,

Surovi Hazarika,

Kevin Houston,

Lingdan Chen,

R. John Lye,

Rosanne Spolski,

Warren J. Leonard,

Brian H. Annex

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305476

Subject(s) - downregulation and upregulation , hindlimb , biology , microbiology and biotechnology , receptor , umbilical vein , in vivo , stat protein , immunology , endocrinology , medicine , apoptosis , in vitro , stat3 , biochemistry , gene

Surgical hindlimb ischemia (HLI) in mice has become a valuable preclinical model to study peripheral arterial disease. We previously identified that the different phenotypic outcomes after HLI across inbred mouse strains is related to a region on the short arm of mouse chromosome 7. The gene coding the interleukin-21 receptor (IL-21R) lies at the peak of association in this region.

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