Regulation of Vascular Endothelial Growth Factor Receptor Function in Angiogenesis by Numb and Numb-Like | Zendy

Max van Lessen | Zendy; Masanori Nakayama | Zendy; Katsuhiro Kato | Zendy; Jung Mo Kim | Zendy; Kozo Kaibuchi | Zendy; Ralf H. Adams | Zendy

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Regulation of Vascular Endothelial Growth Factor Receptor Function in Angiogenesis by Numb and Numb-Like

Author(s) -

Max van Lessen,

Masanori Nakayama,

Katsuhiro Kato,

Jung Mo Kim,

Kozo Kaibuchi,

Ralf H. Adams

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305473

Subject(s) - numb , angiogenesis , microbiology and biotechnology , biology , endothelial stem cell , vascular endothelial growth inhibitor , vascular endothelial growth factor b , endocytosis , vascular endothelial growth factor a , vascular endothelial growth factor , kinase insert domain receptor , signal transduction , endothelium , vascular endothelial growth factor c , receptor , cancer research , endocrinology , biochemistry , in vitro , vegf receptors

Vascular endothelial growth factor (VEGF) signaling is a major regulator of physiological and pathological angiogenesis. VEGF receptor activity is strongly controlled by endocytosis, which can terminate or enhance signal transduction in the angiogenic endothelium, but the exact molecular regulation of these processes remains incompletely understood. We have therefore examined the function of Numb family clathrin-associated sorting proteins in angiogenesis.

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