Reduction of Mitochondria–Endoplasmic Reticulum Interactions by Acetylcholine Protects Human Umbilical Vein Endothelial Cells From Hypoxia/Reoxygenation Injury | Zendy

Xijing He | Zendy; XueYuan Bi | Zendy; Xingzhu Lu | Zendy; Ming Zhao | Zendy; XiaoJiang Yu | Zendy; Lei Sun | Zendy; Man Xu | Zendy; W. Gil Wier | Zendy; Weijin Zang | Zendy

Open Access

Reduction of Mitochondria–Endoplasmic Reticulum Interactions by Acetylcholine Protects Human Umbilical Vein Endothelial Cells From Hypoxia/Reoxygenation Injury

Author(s) -

Xijing He,

XueYuan Bi,

Xingzhu Lu,

Ming Zhao,

XiaoJiang Yu,

Lei Sun,

Man Xu,

W. Gil Wier,

Weijin Zang

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305469

Subject(s) - umbilical vein , endoplasmic reticulum , hypoxia (environmental) , microbiology and biotechnology , mitochondrion , acetylcholine , chemistry , medicine , biology , pharmacology , biochemistry , oxygen , organic chemistry , in vitro

We explored the role of endoplasmic reticulum (ER)-mitochondria Ca(2+) cross talk involving voltage-dependent anion channel-1 (VDAC1)/glucose-regulated protein 75/inositol 1,4,5-trisphosphate receptor 1 complex and mitofusin 2 in endothelial cells during hypoxia/reoxygenation (H/R), and investigated the protective effects of acetylcholine.

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