Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F 2α Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population
Author(s) -
Bing Xiao,
GU Shui-ming,
Mulin Jun Li,
Jun Li,
Tao Bo,
Yuanyang Wang,
Yan Wang,
Shengkai Zuo,
Yujun Shen,
Yu Yu,
Di Chen,
Guilin Chen,
Deping Kong,
Juan Tang,
Qian Liu,
Dong-Rui Chen,
Yong Liu,
Sara Alberti,
Melania Dovizio,
Raffaele Landolfi,
Luciana Mucci,
Peizhi Miao,
Pingjin Gao,
Dingliang Zhu,
Junwen Wang,
Bin Li,
Paola Patrignani,
Ying Yu
Publication year - 2015
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.115.305445
Subject(s) - genotype , three prime untranslated region , essential hypertension , allele , blood pressure , endocrinology , receptor , biology , population , medicine , gene , untranslated region , snp , prostaglandin , single nucleotide polymorphism , microbiology and biotechnology , genetics , messenger rna , environmental health
To investigate whether rs12731181 (A→G) interrupted miR-590-3p-mediated suppression of the prostaglandin F2α receptor (FP) and whether it is associated with essential hypertension in the Chinese population.
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