Dimethylarginine Dimethylaminohydrolase 2 Regulates Nitric Oxide Synthesis and Hemodynamics and Determines Outcome in Polymicrobial Sepsis | Zendy

Simon Lambden | Zendy; Peter D. Kelly | Zendy; Blerina AhmetajShala | Zendy; Zhen Wang | Zendy; Benjamin M. Lee | Zendy; Manasi Nandi | Zendy; Belén Torondel | Zendy; Matthew Delahaye | Zendy; Laura Dowsett | Zendy; Sophie Piper | Zendy; James Tomlinson | Zendy; Ben Caplin | Zendy; Lucy Colman | Zendy; Olga Boruc | Zendy; Anna Slaviero | Zendy; Lan Zhao | Zendy; Eduardo Oliver | Zendy; Sanjay Khadayate | Zendy; Mervyn Singer | Zendy; Francesca Arrigoni | Zendy; James Leiper | Zendy

Open Access

Dimethylarginine Dimethylaminohydrolase 2 Regulates Nitric Oxide Synthesis and Hemodynamics and Determines Outcome in Polymicrobial Sepsis

Author(s) -

Simon Lambden,

Peter D. Kelly,

Blerina AhmetajShala,

Zhen Wang,

Benjamin M. Lee,

Manasi Nandi,

Belén Torondel,

Matthew Delahaye,

Laura Dowsett,

Sophie Piper,

James Tomlinson,

Ben Caplin,

Lucy Colman,

Olga Boruc,

Anna Slaviero,

Lan Zhao,

Eduardo Oliver,

Sanjay Khadayate,

Mervyn Singer,

Francesca Arrigoni,

James Leiper

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305278

Subject(s) - asymmetric dimethylarginine , nitric oxide , knockout mouse , arginine , medicine , nitric oxide synthase , enos , sepsis , in vivo , ex vivo , endocrinology , chemistry , endogeny , pharmacology , biology , biochemistry , amino acid , in vitro , receptor , microbiology and biotechnology

Nitric oxide is a key to numerous physiological and pathophysiological processes. Nitric oxide production is regulated endogenously by 2 methylarginines, asymmetric dimethylarginine (ADMA) and monomethyl-L-arginine. The enzyme that specifically metabolizes asymmetric dimethylarginine and monomethyl-L-arginine is dimethylarginine dimethylaminohydrolase (DDAH). The first isoform dimethylarginine dimethylaminohydrolase 1 has previously been shown to be an important regulator of methylarginines in both health and disease. This study explores for the first time the role of endogenous dimethylarginine dimethylaminohydrolase 2 in regulating cardiovascular physiology and also determines the functional impact of dimethylarginine dimethylaminohydrolase 2 deletion on outcome and immune function in sepsis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research