COX2 Inhibition Reduces Aortic Valve Calcification In Vivo | Zendy

Elaine E. Wirrig | Zendy; M. Victoria Gómez | Zendy; Robert B. Hinton | Zendy; Katherine E. Yutzey | Zendy

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COX2 Inhibition Reduces Aortic Valve Calcification In Vivo

Author(s) -

Elaine E. Wirrig,

M. Victoria Gómez,

Robert B. Hinton,

Katherine E. Yutzey

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.305159

Subject(s) - calcification , klotho , calcinosis , aortic valve , in vivo , gene expression , medicine , pathology , endocrinology , chemistry , biology , gene , biochemistry , kidney , microbiology and biotechnology

Calcific aortic valve disease (CAVD) is a significant cause of morbidity and mortality, which affects ≈1% of the US population and is characterized by calcific nodule formation and stenosis of the valve. Klotho-deficient mice were used to study the molecular mechanisms of CAVD as they develop robust aortic valve (AoV) calcification. Through microarray analysis of AoV tissues from klotho-deficient and wild-type mice, increased expression of the gene encoding cyclooxygenase 2 (COX2; Ptgs2) was found. COX2 activity contributes to bone differentiation and homeostasis, thus the contribution of COX2 activity to AoV calcification was assessed.

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