Open AccessMaternal High-Fat Diet Exaggerates Atherosclerosis in Adult Offspring by Augmenting Periaortic Adipose Tissue-Specific Proinflammatory Response
Author(s) -
Noriyuki Wakana,
Daisuke Irie,
Masakazu Kikai,
Kensuke Terada,
Keita Yamamoto,
Hiroyuki Kawahito,
Taku Kato,
Takehiro Ogata,
Tomomi Ueyama,
Satoaki Matoba,
Hiroyuki Yamada
Publication year - 2015
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.114.305122
Subject(s) - proinflammatory cytokine , offspring , adipose tissue , medicine , endocrinology , biology , inflammation , pregnancy , genetics
Maternal obesity elicits offspring's metabolic disorders via developmental modifications of visceral adipose tissue; however, its effect on atherogenesis remains undefined. Perivascular adipose tissue has recently been implicated in vascular remodeling and vasoreactivity. We hypothesize that developmental modifications of perivascular adipose tissue by maternal high-fat diet (HFD) exposure promotes atherosclerosis in adult offspring.
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