Notch1 Mutation Leads to Valvular Calcification Through Enhanced Myofibroblast Mechanotransduction | Zendy

Joseph Chen | Zendy; Larisa Ryzhova | Zendy; Mary Kathryn Sewell-Loftin | Zendy; Christopher B. Brown | Zendy; Stacey S. Huppert | Zendy; H. Scott Baldwin | Zendy; W. David Merryman | Zendy

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Notch1 Mutation Leads to Valvular Calcification Through Enhanced Myofibroblast Mechanotransduction

Author(s) -

Joseph Chen,

Larisa Ryzhova,

Mary Kathryn Sewell-Loftin,

Christopher B. Brown,

Stacey S. Huppert,

H. Scott Baldwin,

W. David Merryman

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.305095

Subject(s) - myofibroblast , calcification , protein kinase b , pi3k/akt/mtor pathway , biology , microbiology and biotechnology , cancer research , signal transduction , phosphorylation , runx2 , pathology , fibrosis , medicine , osteoblast , in vitro , genetics

Calcific aortic valve disease (CAVD) is a significant cardiovascular disorder, and controversy exists as to whether it is primarily a dystrophic or osteogenic process in vivo. In this study, we sought to clarify the mechanism of CAVD by assessing a genetic mutation, Notch1 heterozygosity, which leads to CAVD with 100% penetrance in humans.

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