Open Access64 Cu-DOTATATE PET/MRI for Detection of Activated Macrophages in Carotid Atherosclerotic Plaques
Author(s) -
Sune Pedersen,
Benjamin Sandholt,
Sune H. Keller,
Adam E. Hansen,
Andreas Clemmensen,
Henrik Sillesen,
Liselotte Højgaard,
R Ripa,
Andreas Kjær
Publication year - 2015
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.114.305067
Subject(s) - carotid endarterectomy , medicine , positron emission tomography , standardized uptake value , nuclear medicine , in vivo , magnetic resonance imaging , somatostatin receptor , pathology , carotid arteries , radiology , receptor , biology , microbiology and biotechnology
A feature of vulnerable atherosclerotic plaques of the carotid artery is high activity and abundance of lesion macrophages. There is consensus that this is of importance for plaque vulnerability, which may lead to clinical events, such as stroke and transient ischemic attack. We used positron emission tomography (PET) and the novel PET ligand [(64)Cu] [1,4,7,10-tetraazacyclododecane-N,N',N″,N‴-tetraacetic acid]-d-Phe1,Tyr3-octreotate ((64)Cu-DOTATATE) to specifically target macrophages via the somatostatin receptor subtype-2 in vivo.
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