Deficiency in Melanocortin 1 Receptor Signaling Predisposes to Vascular Endothelial Dysfunction and Increased Arterial Stiffness in Mice and Humans | Zendy

Petteri Rinne | Zendy; Ari AholaOlli | Zendy; Salla Nuutinen | Zendy; Emilia Koskinen | Zendy; Katja Kaipio | Zendy; Kim Eerola | Zendy; Markus Juonala | Zendy; Mika Kähönen | Zendy; Terho Lehtimäki | Zendy; Olli T. Raitakari | Zendy; Eriika Savontaus | Zendy

Open Access

Deficiency in Melanocortin 1 Receptor Signaling Predisposes to Vascular Endothelial Dysfunction and Increased Arterial Stiffness in Mice and Humans

Author(s) -

Petteri Rinne,

Ari AholaOlli,

Salla Nuutinen,

Emilia Koskinen,

Katja Kaipio,

Kim Eerola,

Markus Juonala,

Mika Kähönen,

Terho Lehtimäki,

Olli T. Raitakari,

Eriika Savontaus

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.305064

Subject(s) - arterial stiffness , endothelial dysfunction , melanocortin , medicine , receptor , endocrinology , signal transduction , endothelium , biology , cardiology , blood pressure , microbiology and biotechnology

The melanocortin 1 receptor (MC1-R) is expressed by vascular endothelial cells and shown to enhance nitric oxide (NO) availability and vasodilator function on pharmacological stimulation. However, the physiological role of MC1-R in the endothelium and its contribution to vascular homeostasis remain unresolved. We investigated whether a lack of functional MC1-R signaling carries a phenotype with predisposition to vascular abnormalities.

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