Open AccessCRISPR-Cas9 Genome Editing of a Single Regulatory Element Nearly Abolishes Target Gene Expression in Mice—Brief Report
Author(s) -
Han Yu,
Orazio J. Slivano,
Christine K. Christie,
Albert W. Cheng,
Joseph M. Miano
Publication year - 2014
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.114.305017
Subject(s) - crispr , biology , genome editing , gene , cas9 , gene knockin , chromatin immunoprecipitation , genetics , mutant , genome , microbiology and biotechnology , gene expression , promoter
To ascertain the importance of a single regulatory element in the control of Cnn1 expression using CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) genome editing.
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