Common Sequence Variants Associated With Coronary Artery Disease Correlate With the Extent of Coronary Atherosclerosis | Zendy

Eyþór Björnsson | Zendy; Daníel F. Guðbjartsson | Zendy; Anna Helgadóttir | Zendy; Þórarinn Guðnason | Zendy; Tómas Guðbjartsson | Zendy; Kristján Eyjólfsson | Zendy; Riyaz S. Patel | Zendy; Nima Ghasemzadeh | Zendy; Guðmar Þorleifsson | Zendy; Arshed A. Quyyumi | Zendy; Unnur Þorsteinsdóttir | Zendy; Guðmundur Þorgeirsson | Zendy; Kári Stéfansson | Zendy

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Common Sequence Variants Associated With Coronary Artery Disease Correlate With the Extent of Coronary Atherosclerosis

Author(s) -

Eyþór Björnsson,

Daníel F. Guðbjartsson,

Anna Helgadóttir,

Þórarinn Guðnason,

Tómas Guðbjartsson,

Kristján Eyjólfsson,

Riyaz S. Patel,

Nima Ghasemzadeh,

Guðmar Þorleifsson,

Arshed A. Quyyumi,

Unnur Þorsteinsdóttir,

Guðmundur Þorgeirsson,

Kári Stéfansson

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304985

Subject(s) - coronary artery disease , medicine , odds ratio , cardiology , confidence interval , coronary atherosclerosis , coronary angiography , single nucleotide polymorphism , coronary arteries , cad , genotype , artery , genetics , myocardial infarction , biology , biochemistry , gene

Single-nucleotide polymorphisms predisposing to coronary artery disease (CAD) have been shown to predict cardiovascular risk in healthy individuals when combined into a genetic risk score (GRS). We examined whether the cumulative burden of known genetic risk variants associated with risk of CAD influences the development and progression of coronary atherosclerosis.

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