Identification of Pathogenic Cardiac CD11c + Macrophages in Nod1-Mediated Acute Coronary Arteritis | Zendy

Yoshitomo Motomura | Zendy; Shunsuke Kanno | Zendy; Kenichi Asano | Zendy; Masato Tanaka | Zendy; Yutaka Hasegawa | Zendy; Hideki Katagiri | Zendy; Takashi Saito | Zendy; Hiromitsu Hara | Zendy; Hisanori Nishio | Zendy; Toshiro Hara | Zendy; Sho Yamasaki | Zendy

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Identification of Pathogenic Cardiac CD11c ⁺ Macrophages in Nod1-Mediated Acute Coronary Arteritis

Author(s) -

Yoshitomo Motomura,

Shunsuke Kanno,

Kenichi Asano,

Masato Tanaka,

Yutaka Hasegawa,

Hideki Katagiri,

Takashi Saito,

Hiromitsu Hara,

Hisanori Nishio,

Toshiro Hara,

Sho Yamasaki

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304846

Subject(s) - cd11c , immunology , inflammation , chemokine , ccr2 , myocarditis , biology , medicine , chemokine receptor , phenotype , biochemistry , gene

Nod1 is an intracellular pattern recognition receptor for bacterial peptidoglycan fragments. We previously reported that a synthetic Nod1 ligand, FK565, induced acute coronary arteritis in mice similar to that of Kawasaki disease. However, the molecular mechanisms underlying this characteristic inflammation have remained elusive.

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