Cysteinyl Leukotriene 1 Receptors as Novel Mechanosensors Mediating Myogenic Tone Together With Angiotensin II Type 1 Receptors—Brief Report | Zendy

Ursula Storch | Zendy; Stephanie Blodow | Zendy; Thomas Gudermann | Zendy; Michael Mederos y Schnitzler | Zendy

Open Access

Cysteinyl Leukotriene 1 Receptors as Novel Mechanosensors Mediating Myogenic Tone Together With Angiotensin II Type 1 Receptors—Brief Report

Author(s) -

Ursula Storch,

Stephanie Blodow,

Thomas Gudermann,

Michael Mederos y Schnitzler

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304844

Subject(s) - candesartan , angiotensin ii , vasoconstriction , vascular smooth muscle , mesenteric arteries , receptor , angiotensin ii receptor type 1 , endocrinology , medicine , microbiology and biotechnology , chemistry , biology , artery , smooth muscle

Myogenic vasoconstriction is mediated by vascular smooth muscle cells of resistance arteries sensing mechanical stretch. Angiotensin II AT1 receptors and in particular AT1BRs in murine vascular smooth muscle cells have been characterized as mechanosensors that cannot fully account for myogenic vasoconstriction observed. Therefore, we aimed at uncovering novel vascular mechanosensors by expression profiling and functional characterization of candidate proteins.

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