ATG16L1 Expression in Carotid Atherosclerotic Plaques Is Associated With Plaque Vulnerability | Zendy

Joëlle Magné | Zendy; Peter SalibaGustafsson | Zendy; Hong Jin | Zendy; Lars Mäegdefessel | Zendy; Kjell Hultenby | Zendy; Annika Wernerson | Zendy; Per Eriksson | Zendy; Anders FrancoCereceda | Zendy; Petri T. Kovanen | Zendy; Isabel Gonçalves | Zendy; Ewa Ehrenborg | Zendy

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ATG16L1 Expression in Carotid Atherosclerotic Plaques Is Associated With Plaque Vulnerability

Author(s) -

Joëlle Magné,

Peter SalibaGustafsson,

Hong Jin,

Lars Mäegdefessel,

Kjell Hultenby,

Annika Wernerson,

Per Eriksson,

Anders FrancoCereceda,

Petri T. Kovanen,

Isabel Gonçalves,

Ewa Ehrenborg

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304840

Subject(s) - medicine , vulnerable plaque , pathology , cardiology

Autophagy has emerged as a cell survival mechanism critical for cellular homeostasis, which may play a protective role in atherosclerosis. ATG16L1, a protein essential for early stages of autophagy, has been implicated in the pathogenesis of Crohn's disease. However, it is unknown whether ATG16L1 is involved in atherosclerosis. Our aim was to analyze ATG16L1 expression in carotid atherosclerotic plaques in relation to markers of plaque vulnerability.

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