Gap Junction Coupling Is Required for Tumor Cell Migration Through Lymphatic Endothelium | Zendy

Natalie O. Karpinich | Zendy; Kathleen M. Caron | Zendy

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Gap Junction Coupling Is Required for Tumor Cell Migration Through Lymphatic Endothelium

Author(s) -

Natalie O. Karpinich,

Kathleen M. Caron

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304752

Subject(s) - lucifer yellow , adrenomedullin , lymphatic system , gap junction , lymphatic endothelium , lymphangiogenesis , microbiology and biotechnology , connexin , endothelial stem cell , biology , cell junction , cancer research , cell , chemistry , pathology , metastasis , intracellular , immunology , cancer , medicine , receptor , in vitro , biochemistry , genetics

The lymphatic vasculature is a well-established conduit for metastasis, but the mechanisms by which tumor cells interact with lymphatic endothelial cells (LECs) to facilitate escape remain poorly understood. Elevated levels of the lymphangiogenic peptide adrenomedullin are found in many tumors, and we previously characterized that its expression is necessary for lymphatic vessel growth within both tumors and sentinel lymph nodes and for distant metastasis.

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