Regulation of Csf1r and Bcl6 in Macrophages Mediates the Stage-Specific Effects of MicroRNA-155 on Atherosclerosis | Zendy

Yuanyuan Wei | Zendy; Mengyu Zhu | Zendy; Judit Corbalán-Campos | Zendy; Kathrin Heyll | Zendy; Christian Weber | Zendy; Andreas Schober | Zendy

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Regulation of Csf1r and Bcl6 in Macrophages Mediates the Stage-Specific Effects of MicroRNA-155 on Atherosclerosis

Author(s) -

Yuanyuan Wei,

Mengyu Zhu,

Judit Corbalán-Campos,

Kathrin Heyll,

Christian Weber,

Andreas Schober

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304723

Subject(s) - microrna , stage (stratigraphy) , mir 155 , cancer research , bcl6 , biology , macrophage , immunology , microbiology and biotechnology , medicine , genetics , gene , in vitro , paleontology , germinal center , b cell , antibody

The function of microRNAs is highly context and cell type dependent because of their highly dynamic expression pattern and the regulation of multiple mRNA targets. MicroRNA-155 (miR-155) plays an important role in the innate immune response by regulating macrophage function; however, the effects of miR-155 in macrophages on atherosclerosis are controversial. We hypothesized that the stage-dependent target selection of miR-155 in macrophages determines its effects on atherosclerosis.

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