Smooth Muscle Cell Deletion of Low-Density Lipoprotein Receptor–Related Protein 1 Augments Angiotensin II–Induced Superior Mesenteric Arterial and Ascending Aortic Aneurysms | Zendy

Frank M. Davis | Zendy; Debra L. Rateri | Zendy; Anju Balakrishnan | Zendy; Deborah A. Howatt | Zendy; Dudley K. Strickland | Zendy; Selen C. Muratoglu | Zendy; Christopher M. Haggerty | Zendy; Brandon K. Fornwalt | Zendy; Lisa A. Cassis | Zendy; Alan Daugherty | Zendy

Open Access

Smooth Muscle Cell Deletion of Low-Density Lipoprotein Receptor–Related Protein 1 Augments Angiotensin II–Induced Superior Mesenteric Arterial and Ascending Aortic Aneurysms

Author(s) -

Frank M. Davis,

Debra L. Rateri,

Anju Balakrishnan,

Deborah A. Howatt,

Dudley K. Strickland,

Selen C. Muratoglu,

Christopher M. Haggerty,

Brandon K. Fornwalt,

Lisa A. Cassis,

Alan Daugherty

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304683

Subject(s) - angiotensin ii , medicine , cardiology , receptor , aortic aneurysm , smooth muscle , chemistry , endocrinology , aorta

Low-density lipoprotein receptor-related protein 1 (LRP1), a multifunctional protein involved in endocytosis and cell signaling pathways, leads to several vascular pathologies when deleted in vascular smooth muscle cells (SMCs). The purpose of this study was to determine whether LRP1 deletion in SMCs influenced angiotensin II-induced arterial pathologies.

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