Chemokines Control Mobilization, Recruitment, and Fate of Monocytes in Atherosclerosis | Zendy

Maik Drechsler | Zendy; Johan Duchêne | Zendy; Oliver Soehnlein | Zendy

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Chemokines Control Mobilization, Recruitment, and Fate of Monocytes in Atherosclerosis

Author(s) -

Maik Drechsler,

Johan Duchêne,

Oliver Soehnlein

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304649

Subject(s) - chemokine , monocyte , macrophage , immunology , mobilization , inflammation , disease , microbiology and biotechnology , biology , chemokine receptor , receptor , medicine , pathology , in vitro , genetics , political science , law

Atherosclerosis is a chronic inflammatory disease of large arteries and, among others, characterized by continuous influx of monocytes into the subendothelial space, subsequent macrophage accumulation, and foam cell formation. Chemokines and their receptors tightly orchestrate monocyte trafficking and fate from birth to death. This brief review summarizes our current understanding of the interplay between monocytes and chemokines entertaining crucial processes in atherosclerosis development, progression, and regression.

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