Osteoprotegerin Deficiency Limits Angiotensin II–Induced Aortic Dilatation and Rupture in the Apolipoprotein E–Knockout Mouse | Zendy

Corey S. Moran | Zendy; Roby J. Jose | Zendy; Erik Biroš | Zendy; Jonathan Golledge | Zendy

Open Access

Osteoprotegerin Deficiency Limits Angiotensin II–Induced Aortic Dilatation and Rupture in the Apolipoprotein E–Knockout Mouse

Author(s) -

Corey S. Moran,

Roby J. Jose,

Erik Biroš,

Jonathan Golledge

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304587

Subject(s) - osteoprotegerin , angiotensin ii , medicine , vascular smooth muscle , apolipoprotein e , endocrinology , aortic aneurysm , abdominal aortic aneurysm , proinflammatory cytokine , aorta , inflammation , aneurysm , surgery , blood pressure , receptor , activator (genetics) , disease , smooth muscle

Mounting evidence links osteoprotegerin with cardiovascular disease. Elevated serum and aortic tissue osteoprotegerin are associated with the presence and growth of abdominal aortic aneurysm in humans; however, a role for osteoprotegerin in abdominal aortic aneurysm pathogenesis remains to be shown. We examined the functional significance of osteoprotegerin in aortic aneurysm using an Opg-deficient mouse model and in vitro investigations.

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