FKBPL Is a Critical Antiangiogenic Regulator of Developmental and Pathological Angiogenesis | Zendy

Anita Yakkundi | Zendy; R. Avery Bennett | Zendy; Ivette Hernández-Negrete | Zendy; JeanMarie Delalande | Zendy; Mary L. Hanna | Zendy; Oksana Lyubomska | Zendy; Ken Arthur | Zendy; Amy Short | Zendy; Hayley D. McKeen | Zendy; Laura L. Nelson | Zendy; Cian M. McCrudden | Zendy; Ross McNally | Zendy; Lana McClements | Zendy; Helen O. McCarthy | Zendy; Alan J. Burns | Zendy; Roy Bicknell | Zendy; Adrien Kissenpfennig | Zendy; Tracy Robson | Zendy

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FKBPL Is a Critical Antiangiogenic Regulator of Developmental and Pathological Angiogenesis

Author(s) -

Anita Yakkundi,

R. Avery Bennett,

Ivette Hernández-Negrete,

JeanMarie Delalande,

Mary L. Hanna,

Oksana Lyubomska,

Ken Arthur,

Amy Short,

Hayley D. McKeen,

Laura L. Nelson,

Cian M. McCrudden,

Ross McNally,

Lana McClements,

Helen O. McCarthy,

Alan J. Burns,

Roy Bicknell,

Adrien Kissenpfennig,

Tracy Robson

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304539

Subject(s) - angiogenesis , zebrafish , biology , microbiology and biotechnology , neovascularization , gene knockdown , sprouting angiogenesis , regulator , ex vivo , in vivo , cancer research , cell culture , biochemistry , genetics , gene

The antitumor effects of FK506-binding protein like (FKBPL) and its extracellular role in angiogenesis are well characterized; however, its role in physiological/developmental angiogenesis and the effect of FKBPL ablation has not been evaluated. This is important as effects of some angiogenic proteins are dosage dependent. Here we evaluate the regulation of FKBPL secretion under angiogenic stimuli, as well as the effect of FKBPL ablation in angiogenesis using mouse and zebrafish models.

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