Anticyclic Citrullinated Protein Antibodies Are Implicated in the Development of Cardiovascular Disease in Rheumatoid Arthritis | Zendy

Nuria Barbarroja | Zendy; C. PérezSánchez | Zendy; P. RuizLimón | Zendy; Carmen Castro | Zendy; M. Á. Aguirre | Zendy; R.M. Carretero | Zendy; P. Segui | Zendy; Yolanda Jiménez | Zendy; Manuela Sanna | Zendy; Antonio RodríguezAriza | Zendy; Eduardo CollantesEstévez | Zendy; Alejandro EscuderoContreras | Zendy; C. López-Pedrera | Zendy

Open Access

Anticyclic Citrullinated Protein Antibodies Are Implicated in the Development of Cardiovascular Disease in Rheumatoid Arthritis

Author(s) -

Nuria Barbarroja,

C. PérezSánchez,

P. RuizLimón,

Carmen Castro,

M. Á. Aguirre,

R.M. Carretero,

P. Segui,

Yolanda Jiménez,

Manuela Sanna,

Antonio RodríguezAriza,

Eduardo CollantesEstévez,

Alejandro EscuderoContreras,

C. López-Pedrera

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304475

Subject(s) - medicine , autoantibody , oxidative stress , proinflammatory cytokine , rheumatoid arthritis , immunology , inflammation , antibody , arthritis

Previous studies have suggested a relationship between anticyclic citrullinated protein (CCP) levels and development of cardiovascular disease in rheumatoid arthritis (RA). However, a limited number of studies have demonstrated an involvement of anti-CCPs in those processes. This study was aimed to define the specific role of these auto-antibodies in the pro-oxidative, inflammatory, and proatherogenic profile observed in leukocytes from RA patients.

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