Tyrosine Kinase Receptor B Protects Against Coronary Artery Disease and Promotes Adult Vasculature Integrity by Regulating Ets1-Mediated VE-Cadherin Expression | Zendy

Hong Jiang | Zendy; Shuhong Huang | Zendy; Xinyun Li | Zendy; Xian Li | Zendy; Yun Zhang | Zendy; Zhe-Yu Chen | Zendy

Open Access

Tyrosine Kinase Receptor B Protects Against Coronary Artery Disease and Promotes Adult Vasculature Integrity by Regulating Ets1-Mediated VE-Cadherin Expression

Author(s) -

Hong Jiang,

Shuhong Huang,

Xinyun Li,

Xian Li,

Yun Zhang,

Zhe-Yu Chen

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304405

Subject(s) - tropomyosin receptor kinase b , ve cadherin , receptor tyrosine kinase , neurotrophin , tyrosine kinase , cancer research , biology , cadherin , receptor , medicine , neurotrophic factors , biochemistry , cell

Tyrosine kinase receptor B (TrkB) is a high-affinity receptor for brain-derived neurotrophic factor. In addition to its nervous system functions, TrkB is also expressed in the cardiovascular system. However, the association of TrkB and coronary artery disease (CAD) remains unknown. We investigated the role of TrkB in the development of CAD and its mechanism.

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