Open AccessInactivation of PI3Kδ Induces Vascular Injury and Promotes Aneurysm Development by Upregulating the AP-1/MMP-12 Pathway in Macrophages
Author(s) -
Lingyun Zheng,
Liying Xing,
Cuiling Zeng,
Teng Wu,
Yali Gui,
Weidong Li,
Tian Lan,
Yongxia Yang,
Quliang Gu,
Cuiling Qi,
Qianqian Zhang,
Futian Tang,
Xiaodong He,
Lijing Wang
Publication year - 2014
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.114.304365
Subject(s) - kinase , tumor necrosis factor alpha , phosphatidylinositol , matrix metalloproteinase , western blot , biology , downregulation and upregulation , microbiology and biotechnology , cancer research , endocrinology , biochemistry , gene
An aneurysm is an inflammatory vascular condition. Phosphatidylinositol 3-kinases δ is highly expressed in leukocytes, and play a key role in innate immunity. However, the link between phosphatidylinositol 3-kinases δ and aneurysm development has not yet been elucidated.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom