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Critical limb ischemia complicates peripheral artery disease leading to tissue damage and amputation. We hypothesized that modifying adipose stromal cells (ASCs) to overexpress human vascular endothelial growth factor 165 (VEGF) would limit ischemic muscle damage to a larger extent than nonmodified ASCs.

Vascular Endothelial Growth Factor Overexpression Does Not Enhance Adipose Stromal Cell–Induced Protection on Muscle Damage in Critical Limb Ischemia