Induction of Dendritic Cell–Mediated T-Cell Activation by Modified but Not Native Low-Density Lipoprotein in Humans and Inhibition by Annexin A5 | Zendy

Anquan Liu | Zendy; Julia Ming | Zendy; Roland Fiskesund | Zendy; Ewa Ninio | Zendy; SoniaAthina Karabina | Zendy; Claes Bergmark | Zendy; Anna G. Frostegård | Zendy; Johan Frostegård | Zendy

Open Access

Induction of Dendritic Cell–Mediated T-Cell Activation by Modified but Not Native Low-Density Lipoprotein in Humans and Inhibition by Annexin A5

Author(s) -

Anquan Liu,

Julia Ming,

Roland Fiskesund,

Ewa Ninio,

SoniaAthina Karabina,

Claes Bergmark,

Anna G. Frostegård,

Johan Frostegård

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304342

Subject(s) - t cell , annexin , microbiology and biotechnology , chemistry , inflammation , cd40 , annexin a2 , cell growth , cytotoxic t cell , cell , biology , immunology , immune system , biochemistry , in vitro

Atherosclerosis is an inflammatory disease, where activated immunocompetent cells, including dendritic cells (DCs) and T cells are abundant in plaques. Low-density lipoprotein modified either by oxidation (oxLDL) or by human group X-secreted phospholipase A2 (LDLx) and heat shock proteins (HSP), especially HSP60 and 90, have been implicated in atherosclerosis. We previously reported that Annexin A5 inhibits inflammatory effects of phospholipids, decreases vascular inflammation and improves vascular function in apolipoprotein E(-/-) mice. Here, we focus on the LDLx effects on human DCs and T cells.

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