Canonical Wnt Signaling Induces Vascular Endothelial Dysfunction via p66 Shc -Regulated Reactive Oxygen Species | Zendy

Ajit Vikram | Zendy; YoungRae Kim | Zendy; Santosh Kumar | Zendy; Asma Naqvi | Zendy; Timothy A. Hoffman | Zendy; Ajay Kumar | Zendy; Francis J. Miller | Zendy; CukSeong Kim | Zendy; Kaikobad Irani | Zendy

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Canonical Wnt Signaling Induces Vascular Endothelial Dysfunction via p66 ^Shc -Regulated Reactive Oxygen Species

Author(s) -

Ajit Vikram,

YoungRae Kim,

Santosh Kumar,

Asma Naqvi,

Timothy A. Hoffman,

Ajay Kumar,

Francis J. Miller,

CukSeong Kim,

Kaikobad Irani

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304338

Subject(s) - reactive oxygen species , wnt signaling pathway , oxygen , chemistry , endothelial dysfunction , microbiology and biotechnology , signal transduction , biology , biochemistry , medicine , organic chemistry

Reactive oxygen species regulate canonical Wnt signaling. However, the role of the redox regulatory protein p66(Shc) in the canonical Wnt pathway is not known. We investigated whether p66(Shc) is essential for canonical Wnt signaling in the endothelium and determined whether the canonical Wnt pathway induces vascular endothelial dysfunction via p66(Shc)-mediated oxidative stress.

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