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Reactive oxygen species regulate canonical Wnt signaling. However, the role of the redox regulatory protein p66(Shc) in the canonical Wnt pathway is not known. We investigated whether p66(Shc) is essential for canonical Wnt signaling in the endothelium and determined whether the canonical Wnt pathway induces vascular endothelial dysfunction via p66(Shc)-mediated oxidative stress.

Canonical Wnt Signaling Induces Vascular Endothelial Dysfunction via p66 Shc -Regulated Reactive Oxygen Species

Canonical Wnt Signaling Induces Vascular Endothelial Dysfunction via p66 ^Shc -Regulated Reactive Oxygen Species