Early Development of Calcific Aortic Valve Disease and Left Ventricular Hypertrophy in a Mouse Model of Combined Dyslipidemia and Type 2 Diabetes Mellitus
Author(s) -
Khaï Le Quang,
Rihab Bouchareb,
Dominic Lachance,
Marc-André Laplante,
Diala El Husseini,
MarieChloé Boulanger,
Dominique Fournier,
Xiang Ping Fang,
Rita Kohen Avramoglu,
Philippe Pîbarot,
Yves Deshaies,
Gary Sweeney,
Patrick Mathieu,
André Marette
Publication year - 2014
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.114.304205
Subject(s) - medicine , apolipoprotein b , dyslipidemia , endocrinology , diabetes mellitus , left ventricular hypertrophy , ldl receptor , calcification , aortic valve , cholesterol , cardiology , lipoprotein , blood pressure
This study aimed to determine the potential impact of type 2 diabetes mellitus on left ventricular dysfunction and the development of calcified aortic valve disease using a dyslipidemic mouse model prone to developing type 2 diabetes mellitus.
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