Open AccessThe Nuclear Receptor FXR Uncouples the Actions of miR-33 From SREBP-2
Author(s) -
Elizabeth J. Tarling,
Hannah Ahn,
Thomas Q. de Aguiar Vallim
Publication year - 2015
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.114.304179
Subject(s) - farnesoid x receptor , sterol regulatory element binding protein , nuclear receptor , chromatin immunoprecipitation , transcription factor , microbiology and biotechnology , biology , nuclear receptor coactivator 1 , medicine , chemistry , endocrinology , gene expression , gene , biochemistry , promoter
To determine whether activation of farnesoid X receptor (FXR) alters cellular and plasma cholesterol homeostasis as a result of regulation of Srebp-2 and miR-33.
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