Apolipoprotein A-I Increases Insulin Secretion and Production From Pancreatic β-Cells via a G-Protein-cAMP-PKA-FoxO1–Dependent Mechanism | Zendy

Blake J. Cochran | Zendy; Radjesh J. Bisoendial | Zendy; Liming Hou | Zendy; Elias N. Glaros | Zendy; Jérémie Rossy | Zendy; Shane R. Thomas | Zendy; Philip J. Barter | Zendy; Kerry-Anne Rye | Zendy

Open Access

Apolipoprotein A-I Increases Insulin Secretion and Production From Pancreatic β-Cells via a G-Protein-cAMP-PKA-FoxO1–Dependent Mechanism

Author(s) -

Blake J. Cochran,

Radjesh J. Bisoendial,

Liming Hou,

Elias N. Glaros,

Jérémie Rossy,

Shane R. Thomas,

Philip J. Barter,

Kerry-Anne Rye

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304131

Subject(s) - mechanism (biology) , secretion , endocrinology , medicine , insulin , apolipoprotein b , chemistry , biology , cholesterol , philosophy , epistemology

Therapeutic interventions that increase plasma levels of high-density lipoproteins and apolipoprotein A-I (apoA-I) A-I, the major high-density lipoprotein apolipoprotein, improve glycemic control in people with type 2 diabetes mellitus. High-density lipoproteins and apoA-I also enhance insulin synthesis and secretion in isolated pancreatic islets and clonal β-cell lines. This study identifies the signaling pathways that mediate these effects.

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