Platelet Endothelial Cell Adhesion Molecule-1 Inhibits Platelet Response to Thrombin and von Willebrand Factor by Regulating the Internalization of Glycoprotein Ib via AKT/Glycogen Synthase Kinase-3/Dynamin and Integrin αIIbβ3 | Zendy

Chris I. Jones | Zendy; Tanya Sage | Zendy; Leonardo A. Moraes | Zendy; Sakthivel Vaiyapuri | Zendy; Umara Hussain | Zendy; Katherine L. Tucker | Zendy; Natasha Barrett | Zendy; Jonathan M. Gibbins | Zendy

Open Access

Platelet Endothelial Cell Adhesion Molecule-1 Inhibits Platelet Response to Thrombin and von Willebrand Factor by Regulating the Internalization of Glycoprotein Ib via AKT/Glycogen Synthase Kinase-3/Dynamin and Integrin αIIbβ3

Author(s) -

Chris I. Jones,

Tanya Sage,

Leonardo A. Moraes,

Sakthivel Vaiyapuri,

Umara Hussain,

Katherine L. Tucker,

Natasha Barrett,

Jonathan M. Gibbins

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304097

Subject(s) - internalization , glycoprotein ib , microbiology and biotechnology , chemistry , gsk 3 , thrombin , platelet glycoprotein gpib ix complex , disintegrin , platelet activation , integrin , platelet , biochemistry , platelet membrane glycoprotein , phosphorylation , receptor , biology , immunology , metalloproteinase , matrix metalloproteinase

Platelet endothelial cell adhesion molecule-1 (PECAM-1) regulates platelet response to multiple agonists. How this immunoreceptor tyrosine-based inhibitory motif-containing receptor inhibits G protein-coupled receptor-mediated thrombin-induced activation of platelets is unknown.

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