Cholesterol Loading Reprograms the MicroRNA-143/145–Myocardin Axis to Convert Aortic Smooth Muscle Cells to a Dysfunctional Macrophage-Like Phenotype | Zendy

Yuliya Vengrenyuk | Zendy; Hitoo Nishi | Zendy; Xiaochun Long | Zendy; Mireille Ouimet | Zendy; Nazir Savji | Zendy; Fernando O. Martínez | Zendy; Courtney P. Cassella | Zendy; Kathryn J. Moore | Zendy; Stephen A. Ramsey | Zendy; Joseph M. Miano | Zendy; Edward A. Fisher | Zendy

Open Access

Cholesterol Loading Reprograms the MicroRNA-143/145–Myocardin Axis to Convert Aortic Smooth Muscle Cells to a Dysfunctional Macrophage-Like Phenotype

Author(s) -

Yuliya Vengrenyuk,

Hitoo Nishi,

Xiaochun Long,

Mireille Ouimet,

Nazir Savji,

Fernando O. Martínez,

Courtney P. Cassella,

Kathryn J. Moore,

Stephen A. Ramsey,

Joseph M. Miano,

Edward A. Fisher

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304029

Subject(s) - myocardin , microrna , phenotype , smooth muscle , dysfunctional family , biology , macrophage , microbiology and biotechnology , anatomy , pathology , endocrinology , medicine , genetics , gene , gene expression , serum response factor , in vitro , clinical psychology

We previously showed that cholesterol loading in vitro converts mouse aortic vascular smooth muscle cells (VSMC) from a contractile state to one resembling macrophages. In human and mouse atherosclerotic plaques, it has become appreciated that ≈40% of cells classified as macrophages by histological markers may be of VSMC origin. Therefore, we sought to gain insight into the molecular regulation of this clinically relevant process.

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