Reversal of Hypoxia in Murine Atherosclerosis Prevents Necrotic Core Expansion by Enhancing Efferocytosis | Zendy

Elke Marsch | Zendy; Thomas Theelen | Zendy; Jasper A. F. Demandt | Zendy; Mike L. J. Jeurissen | Zendy; Mathijs van Gink | Zendy; Robin Verjans | Zendy; Anique Janssen | Zendy; Jack P.M. Cleutjens | Zendy; Steven J.R. Meex | Zendy; Marjo M. P. C. Donners | Zendy; Guido R.M.M. Haenen | Zendy; Casper G. Schalkwijk | Zendy; Ludwig J. Dubois | Zendy; Philippe Lambin | Zendy; Ziad Mallat | Zendy; Marion J. Gijbels | Zendy; Johan W. M. Heemskerk | Zendy; Edward A. Fisher | Zendy; Erik A.L. Biessen | Zendy; Ben Janssen | Zendy; Mat J.A.P. Daemen | Zendy; Judith C. Sluimer | Zendy

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Reversal of Hypoxia in Murine Atherosclerosis Prevents Necrotic Core Expansion by Enhancing Efferocytosis

Author(s) -

Elke Marsch,

Thomas Theelen,

Jasper A. F. Demandt,

Mike L. J. Jeurissen,

Mathijs van Gink,

Robin Verjans,

Anique Janssen,

Jack P.M. Cleutjens,

Steven J.R. Meex,

Marjo M. P. C. Donners,

Guido R.M.M. Haenen,

Casper G. Schalkwijk,

Ludwig J. Dubois,

Philippe Lambin,

Ziad Mallat,

Marion J. Gijbels,

Johan W. M. Heemskerk,

Edward A. Fisher,

Erik A.L. Biessen,

Ben Janssen,

Mat J.A.P. Daemen,

Judith C. Sluimer

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.304023

Subject(s) - carbogen , efferocytosis , hypoxia (environmental) , ldl receptor , tunel assay , terminal deoxynucleotidyl transferase , pathology , apoptosis , medicine , biology , endocrinology , chemistry , oxygenation , lipoprotein , cholesterol , in vitro , macrophage , oxygen , biochemistry , organic chemistry

Advanced murine and human plaques are hypoxic, but it remains unclear whether plaque hypoxia is causally related to atherogenesis. Here, we test the hypothesis that reversal of hypoxia in atherosclerotic plaques by breathing hyperoxic carbogen gas will prevent atherosclerosis.

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