Open AccessRegulation of High-Density Lipoprotein on Hematopoietic Stem/Progenitor Cells in Atherosclerosis Requires Scavenger Receptor Type BI Expression
Author(s) -
Mingming Gao,
Dong Zhao,
Sarah Schouteden,
Mary G. SorciThomas,
Paul P. Van Veldhoven,
Kristel Eggermont,
Chaojie Liu,
Catherine M. Verfaillie,
Yingmei Feng
Publication year - 2014
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.114.304006
Subject(s) - progenitor cell , haematopoiesis , bone marrow , scavenger receptor , ldl receptor , stem cell , medicine , endocrinology , biology , chemistry , cancer research , lipoprotein , immunology , microbiology and biotechnology , cholesterol
Recently, we demonstrated that scavenger receptor type BI (SR-BI), a high-density lipoprotein (HDL) receptor, was expressed on murine hematopoietic stem/progenitor cells (HSPC) and infusion of reconstituted HDL and purified human apolipoprotein A-I (apoA-I) suppressed HSPC proliferation. We hypothesized that SR-B1 expression is required for the observed antiproliferative effects of HDL on HSPC.
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