Common and Distinctive Pathogenetic Features of Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia 1 and Hereditary Hemorrhagic Telangiectasia 2 Animal Models—Brief Report | Zendy

Eva M. Garrido-Martín | Zendy; HaLong Nguyen | Zendy; Tyler A. Cunningham | Zendy; Sewoon Choe | Zendy; Zhihua Jiang | Zendy; Helen M. Arthur | Zendy; Young Jae Lee | Zendy; S. Paul Oh | Zendy

Open Access

Common and Distinctive Pathogenetic Features of Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia 1 and Hereditary Hemorrhagic Telangiectasia 2 Animal Models—Brief Report

Author(s) -

Eva M. Garrido-Martín,

HaLong Nguyen,

Tyler A. Cunningham,

Sewoon Choe,

Zhihua Jiang,

Helen M. Arthur,

Young Jae Lee,

S. Paul Oh

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.303984

Subject(s) - telangiectasia , mucocutaneous zone , pathology , medicine , acvrl1 , endoglin , biology , microbiology and biotechnology , disease , stem cell , cd34

Hereditary hemorrhagic telangiectasia is a genetic disorder characterized by visceral and mucocutaneous arteriovenous malformations (AVMs). Clinically indistinguishable hereditary hemorrhagic telangiectasia 1 and hereditary hemorrhagic telangiectasia 2 are caused by mutations in ENG and ALK1, respectively. In this study, we have compared the development of visceral and mucocutaneous AVMs in adult stages between Eng- and Alk1-inducible knockout (iKO) models.

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