α5β1 Integrin Signaling Mediates Oxidized Low-Density Lipoprotein–Induced Inflammation and Early Atherosclerosis | Zendy

Arif Yurdagul | Zendy; Jonette Green | Zendy; Patrick Albert | Zendy; Marshall C. McInnis | Zendy; Andrew P. Mazar | Zendy; A. Wayne Orr | Zendy

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α5β1 Integrin Signaling Mediates Oxidized Low-Density Lipoprotein–Induced Inflammation and Early Atherosclerosis

Author(s) -

Arif Yurdagul,

Jonette Green,

Patrick Albert,

Marshall C. McInnis,

Andrew P. Mazar,

A. Wayne Orr

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.303863

Subject(s) - fibronectin , microbiology and biotechnology , cell adhesion molecule , integrin , cell adhesion , chemistry , inflammation , proinflammatory cytokine , signal transduction , focal adhesion , extracellular matrix , biology , receptor , immunology , cell , biochemistry

Endothelial cell activation drives early atherosclerotic plaque formation. Both fibronectin deposition and accumulation of oxidized low-density lipoprotein (oxLDL) occur early during atherogenesis, and both are implicated in enhanced endothelial cell activation. However, interplay between these responses has not been established. The objective of our study was to determine whether endothelial matrix composition modulates the inflammatory properties of oxLDL.

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