Polymorphisms in Catechol- O -Methyltransferase Modify Treatment Effects of Aspirin on Risk of Cardiovascular Disease | Zendy

Kathryn T. Hall | Zendy; Christopher P. Nelson | Zendy; Roger B. Davis | Zendy; Julie E. Buring | Zendy; Irving Kirsch | Zendy; Murray A. Mittleman | Zendy; Joseph Loscalzo | Zendy; Nilesh J. Samani | Zendy; Paul M. Ridker | Zendy; Ted J. Kaptchuk | Zendy; Daniel I. Chasman | Zendy

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Polymorphisms in Catechol- O -Methyltransferase Modify Treatment Effects of Aspirin on Risk of Cardiovascular Disease

Author(s) -

Kathryn T. Hall,

Christopher P. Nelson,

Roger B. Davis,

Julie E. Buring,

Irving Kirsch,

Murray A. Mittleman,

Joseph Loscalzo,

Nilesh J. Samani,

Paul M. Ridker,

Ted J. Kaptchuk,

Daniel I. Chasman

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.303845

Subject(s) - rs4680 , aspirin , medicine , coronary artery disease , hazard ratio , population , placebo , catechol o methyl transferase , bioinformatics , endocrinology , oncology , confidence interval , genetics , allele , biology , pathology , alternative medicine , environmental health , gene

Catechol-O-methyltransferase (COMT), a key enzyme in catecholamine metabolism, is implicated in cardiovascular, sympathetic, and endocrine pathways. This study aimed to confirm preliminary association of COMT genetic variation with incident cardiovascular disease (CVD). It further aimed to evaluate whether aspirin, a commonly used CVD prevention agent, modified the potential association of COMT with incident CVD.

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