Transcriptional Regulation of Endothelial Arginase 2 by Histone Deacetylase 2 | Zendy

Deepesh Pandey | Zendy; Gautam Sikka | Zendy; Yehudit Bergman | Zendy; Jae Hyung Kim | Zendy; Sungwoo Ryoo | Zendy; Lewis H. Romer | Zendy; Dan E. Berkowitz | Zendy

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Transcriptional Regulation of Endothelial Arginase 2 by Histone Deacetylase 2

Author(s) -

Deepesh Pandey,

Gautam Sikka,

Yehudit Bergman,

Jae Hyung Kim,

Sungwoo Ryoo,

Lewis H. Romer,

Dan E. Berkowitz

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.303685

Subject(s) - arginase , histone deacetylase , histone , chemistry , histone deacetylase 5 , cancer research , microbiology and biotechnology , biology , biochemistry , gene , arginine , amino acid

Arginase 2 (Arg2) is a critical target in atherosclerosis because it controls endothelial nitric oxide, proliferation, fibrosis, and inflammation. Regulators of Arg2 transcription in the endothelium have not been characterized. The goal of the current study is to determine the role of specific histone deacetylases (HDACs) in the regulation of endothelial Arg2 transcription and endothelial function.

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