Rap1b in Smooth Muscle and Endothelium Is Required for Maintenance of Vascular Tone and Normal Blood Pressure | Zendy

Sribalaji Lakshmikanthan | Zendy; Bartosz J. Zieba | Zendy; ZhiDong Ge | Zendy; Ko Momotani | Zendy; Xiaodong Zheng | Zendy; Hayley Lund | Zendy; Mykhaylo V. Artamonov | Zendy; Jason E. Maas | Zendy; Anikó Szabó | Zendy; David X. Zhang | Zendy; John A. Auchampach | Zendy; David L. Mattson | Zendy; Avril V. Somlyo | Zendy; Magdalena ChrzanowskaWodnicka | Zendy

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Rap1b in Smooth Muscle and Endothelium Is Required for Maintenance of Vascular Tone and Normal Blood Pressure

Author(s) -

Sribalaji Lakshmikanthan,

Bartosz J. Zieba,

ZhiDong Ge,

Ko Momotani,

Xiaodong Zheng,

Hayley Lund,

Mykhaylo V. Artamonov,

Jason E. Maas,

Anikó Szabó,

David X. Zhang,

John A. Auchampach,

David L. Mattson,

Avril V. Somlyo,

Magdalena ChrzanowskaWodnicka

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.303678

Subject(s) - medicine , endocrinology , vascular smooth muscle , angiotensin ii , thromboxane a2 , muscle hypertrophy , endothelium , vasodilation , blood pressure , platelet , smooth muscle

Small GTPase Ras-related protein 1 (Rap1b) controls several basic cellular phenomena, and its deletion in mice leads to several cardiovascular defects, including impaired adhesion of blood cells and defective angiogenesis. We found that Rap1b(-/-) mice develop cardiac hypertrophy and hypertension. Therefore, we examined the function of Rap1b in regulation of blood pressure.

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