Open AccessLysyl Oxidases Play a Causal Role in Vascular Remodeling in Clinical and Experimental Pulmonary Arterial Hypertension
Author(s) -
Alexander H. Nave,
Ivana Mižíková,
Gero Niess,
Heiko Steenbock,
Frank Reichenberger,
María L. Talavera,
Florian Veit,
Susanne Herold,
Konstantin Mayer,
István Vadász,
Norbert Weißmann,
Werner Seeger,
Jürgen Brinckmann,
Rory E. Morty
Publication year - 2014
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.114.303534
Subject(s) - lysyl oxidase , pulmonary hypertension , hypoxia (environmental) , vascular remodelling in the embryo , pulmonary artery , right ventricular hypertrophy , lung , medicine , pathology , elastin , vascular smooth muscle , cardiology , extracellular matrix , biology , chemistry , microbiology and biotechnology , smooth muscle , oxygen , organic chemistry
Pulmonary vascular remodeling, the pathological hallmark of pulmonary arterial hypertension, is attributed to proliferation, apoptosis resistance, and migration of vascular cells. A role of dysregulated matrix cross-linking and stability as a pathogenic mechanism has received little attention. We aimed to assess whether matrix cross-linking enzymes played a causal role in experimental pulmonary hypertension (PH).
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