Determinants of Flow-Mediated Outward Remodeling in Female Rodents | Zendy

Kahena Tarhouni | Zendy; AnneLaure Guihot | Zendy; Emilie Vessières | Zendy; Bertrand Toutain | Zendy; Vincent Procaccio | Zendy; Linda Grimaud | Zendy; Laurent Loufrani | Zendy; Françoise Lenfant | Zendy; JeanFrançois Arnal | Zendy; Daniel Henrion | Zendy

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Determinants of Flow-Mediated Outward Remodeling in Female Rodents

Author(s) -

Kahena Tarhouni,

AnneLaure Guihot,

Emilie Vessières,

Bertrand Toutain,

Vincent Procaccio,

Linda Grimaud,

Laurent Loufrani,

Françoise Lenfant,

JeanFrançois Arnal,

Daniel Henrion

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.303404

Subject(s) - medicine , endocrinology , estrogen , ovariectomized rat , blood flow , enos , estrogen receptor , nitric oxide synthase , nitric oxide , biology , cancer , breast cancer

Flow (shear stress)-mediated outward remodeling (FMR) of resistance arteries is a key adaptive process allowing collateral growth after arterial occlusion but declining with age. 17-β-estradiol (E2) has a key role in this process through activation of estrogen receptor α (ERα). Thus, we investigated the impact of age and timing for estrogen efficacy on FMR.

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