Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N -Oxide, a Proatherogenic Metabolite of Choline and l -Carnitine | Zendy

Jaana Hartiala | Zendy; Brian J. Bennett | Zendy; W.H. Wilson Tang | Zendy; Zeneng Wang | Zendy; Alexandre F.R. Stewart | Zendy; Robert J. Roberts | Zendy; Ruth McPherson | Zendy; Aldons J. Lusis | Zendy; Stanley L. Hazen | Zendy; Hooman Allayee | Zendy

Open Access

Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N -Oxide, a Proatherogenic Metabolite of Choline and l -Carnitine

Author(s) -

Jaana Hartiala,

Brian J. Bennett,

W.H. Wilson Tang,

Zeneng Wang,

Alexandre F.R. Stewart,

Robert J. Roberts,

Ruth McPherson,

Aldons J. Lusis,

Stanley L. Hazen,

Hooman Allayee

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.303252

Subject(s) - trimethylamine n oxide , biology , locus (genetics) , quantitative trait locus , genome wide association study , genetics , carnitine , genetic association , choline , expression quantitative trait loci , gene , genotyping , single nucleotide polymorphism , trimethylamine , genotype , biochemistry

Elevated levels of plasma trimethylamine N-oxide (TMAO), the product of gut microbiome and hepatic-mediated metabolism of dietary choline and L-carnitine, have recently been identified as a novel risk factor for the development of atherosclerosis in mice and humans. The goal of this study was to identify the genetic factors associated with plasma TMAO levels.

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