Signaling Pathways in the Specification of Arteries and Veins | Zendy

Monica Corada | Zendy; Marco Morini | Zendy; Elisabetta Dejana | Zendy

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Signaling Pathways in the Specification of Arteries and Veins

Author(s) -

Monica Corada,

Marco Morini,

Elisabetta Dejana

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.303218

Subject(s) - wnt signaling pathway , biology , effector , notch signaling pathway , microbiology and biotechnology , endothelial stem cell , signal transduction , endothelium , transcription factor , neuroscience , anatomy , endocrinology , genetics , gene , in vitro

The establishment of arterial and venous identity of endothelial cells is critical for the proper anatomic configuration and function of the vascular tree. Arterial and venous specification of endothelial cells is determined by genetic factors, although surrounding cells and hemodynamic forces may also contribute to vascular remodeling. This review provides an overview of the signaling pathways and related transcription factors implicated in differentiation of endothelial cells. We will discuss, in particular, the role of upstream and downstream effectors of Wnt, Sox, and Notch pathways. The understanding of the molecular mechanisms that orchestrate endothelial differentiation may have therapeutic relevance for diseases such as atherosclerosis, arteriovenous malformations, aneurysms, and others.

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