Factor XI Regulates Pathological Thrombus Formation on Acutely Ruptured Atherosclerotic Plaques | Zendy

Maurits L. van Montfoort | Zendy; Marijke J. E. Kuijpers | Zendy; Véronique L. Knaup | Zendy; Sanjay Bhanot | Zendy; Brett P. Monia | Zendy; Joris J. T. H. Roelofs | Zendy; Johan W. M. Heemskerk | Zendy; Joost C.M. Meijers | Zendy

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Factor XI Regulates Pathological Thrombus Formation on Acutely Ruptured Atherosclerotic Plaques

Author(s) -

Maurits L. van Montfoort,

Marijke J. E. Kuijpers,

Véronique L. Knaup,

Sanjay Bhanot,

Brett P. Monia,

Joris J. T. H. Roelofs,

Johan W. M. Heemskerk,

Joost C.M. Meijers

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.303209

Subject(s) - thrombus , tissue factor , medicine , fibrin , pathology , platelet , inflammation , coagulation , immunology

Coagulation factor XI is proposed as therapeutic target for anticoagulation. However, it is still unclear whether the antithrombotic properties of factor XI inhibitors influence atherosclerotic disease and atherothrombosis. Our aim is to investigate whether factor XI antisense oligonucleotides could prevent thrombus formation on acutely ruptured atherosclerotic plaques.

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