Open AccessInducible Metabolic Adaptation Promotes Mesenchymal Stem Cell Therapy for Ischemia
Author(s) -
Hongming Zhu,
Aijun Sun,
Yunzeng Zou,
Junbo Ge
Publication year - 2014
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.114.303194
Subject(s) - glycogen , glycogenesis , glycogen synthase , biology , stem cell , mesenchymal stem cell , gsk3b , gsk 3 , glycogen branching enzyme , glycogen phosphorylase , microbiology and biotechnology , endocrinology , medicine , signal transduction
Ischemic tissue is an environment with limited oxygen and nutrition availability. The poor retention of mesenchymal stem cells (MSC) in ischemic tissues greatly limits their therapeutic potential. The aim of this study was to determine whether and how inducible metabolic adaptation enhances MSC survival and therapy under ischemia.
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