Lymphatic Vessel Insufficiency in Hypercholesterolemic Mice Alters Lipoprotein Levels and Promotes Atherogenesis | Zendy

Taina Vuorio | Zendy; Harri Nurmi | Zendy; Karen S. Moulton | Zendy; Jere Kurkipuro | Zendy; Marius R. Robciuc | Zendy; Miina K. Öhman | Zendy; Suvi E. Hein | Zendy; Haritha Samaranayake | Zendy; Tommi Heikura | Zendy; Kari Alitalo | Zendy; Seppo YläHerttuala | Zendy

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Lymphatic Vessel Insufficiency in Hypercholesterolemic Mice Alters Lipoprotein Levels and Promotes Atherogenesis

Author(s) -

Taina Vuorio,

Harri Nurmi,

Karen S. Moulton,

Jere Kurkipuro,

Marius R. Robciuc,

Miina K. Öhman,

Suvi E. Hein,

Haritha Samaranayake,

Tommi Heikura,

Kari Alitalo,

Seppo YläHerttuala

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.114.302528

Subject(s) - lymphatic vessel , apolipoprotein b , lymphatic system , ldl receptor , chylomicron , medicine , endocrinology , lipoprotein , cholesterol , triglyceride , receptor , biology , very low density lipoprotein , pathology , cancer , metastasis

Lymphatic vessels collect extravasated fluid and proteins from tissues to blood circulation as well as play an essential role in lipid metabolism by taking up intestinal chylomicrons. Previous studies have shown that impairment of lymphatic vessel function causes lymphedema and fat accumulation, but clear connections between arterial pathologies and lymphatic vessels have not been described.

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