Nicotinic Acid Activates the Capsaicin Receptor TRPV1 | Zendy

Linlin Ma | Zendy; Bo Hyun Lee | Zendy; Rongrong Mao | Zendy; Anping Cai | Zendy; YunFang Jia | Zendy; Heather L. Clifton | Zendy; Saul Schaefer | Zendy; Lin Xu | Zendy; Jie Zheng | Zendy

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Nicotinic Acid Activates the Capsaicin Receptor TRPV1

Author(s) -

Linlin Ma,

Bo Hyun Lee,

Rongrong Mao,

Anping Cai,

YunFang Jia,

Heather L. Clifton,

Saul Schaefer,

Lin Xu,

Jie Zheng

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.303346

Subject(s) - trpv1 , capsaicin , chemistry , nicotinic agonist , transient receptor potential channel , pharmacology , biochemistry , receptor , medicine

Nicotinic acid (also known as niacin or vitamin B3), widely used to treat dyslipidemias, represents an effective and safe means to reduce the risk of mortality from cardiovascular disease. Nonetheless, a substantial fraction of patients discontinue treatment because of a strong side effect of cutaneous vasodilation, commonly termed flushing. In the present study, we tested the hypothesis that nicotinic acid causes flushing partially by activating the capsaicin receptor TRPV1, a polymodal cellular sensor that mediates the flushing response on consumption of spicy food.

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