CXCR3 Controls T-Cell Accumulation in Fat Inflammation | Zendy

Viviane Z. Rocha | Zendy; Eduardo J. Folco | Zendy; Cafer Ozdemir | Zendy; Yuri Sheikine | Zendy; Thomas Christen | Zendy; Galina K. Sukhova | Zendy; Eva H.C. Tang | Zendy; Márcio Sommer Bittencourt | Zendy; Raúl D. Santos | Zendy; Andrew D. Luster | Zendy; David E. Cohen | Zendy; Peter Libby | Zendy

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CXCR3 Controls T-Cell Accumulation in Fat Inflammation

Author(s) -

Viviane Z. Rocha,

Eduardo J. Folco,

Cafer Ozdemir,

Yuri Sheikine,

Thomas Christen,

Galina K. Sukhova,

Eva H.C. Tang,

Márcio Sommer Bittencourt,

Raúl D. Santos,

Andrew D. Luster,

David E. Cohen,

Peter Libby

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.303133

Subject(s) - cxcr3 , inflammation , endocrinology , medicine , adipose tissue , proinflammatory cytokine , t cell , chemokine , diet induced obese , biology , immunology , chemokine receptor , insulin resistance , obesity , immune system

Obesity associates with increased numbers of inflammatory cells in adipose tissue (AT), including T cells, but the mechanism of T-cell recruitment remains unknown. This study tested the hypothesis that the chemokine (C-X-C motif) receptor 3 (CXCR3) participates in T-cell accumulation in AT of obese mice and thus in the regulation of local inflammation and systemic metabolism.

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